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    Today, if you ask any marketer what his biggest challenges are you will no doubt hear Return on Investment (ROI) at the top of their list. With competitive pressures,
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    businesses more focused on profitable growth, and an increased need to do more with less, marketing professionals need to generate favorable returns on most – if not al
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    l of their marketing campaigns.

    Upon first blush, this looks rather simple. Just take the total cost of your campaign, track it through to conversion and determine th
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    at the revenue generated is greater than the expense. However, most people make the mistake of assuming that calculating ROI is only involves direct expenses and reven
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    ue. There are other factors to consider when determining your return on investment.

    In a moment, I’ll show you a quick formula to help calculate ROI, but before I do,
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    let me explain the types of expenses you need to consider:

    Direct Expenses. Any cash outlay you have to develop, create, and distribute your marketing campaign is co
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    nsidered a direct expense. For example, if you’re doing a direct marketing campaign, you’ll have to print your mailer, pay for postage, and offer an incentive. All of
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    these factors are direct expenses because they cost you money.

    If you’re marketing online with Google Adwords or a similar type of service, you’re paying for each and
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    every click – this is considered a direct expense.

    Indirect Expenses. An indirect expense is something you spend to in conjunction with your marketing efforts but do
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    esn’t necessarily involve a cash outlay. For example, if you pay a copywriter or designer to help with your creative, their time and expense must be considered. Other
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    indirect expenses might include your overhead such as rent, electric, phone, insurance, etc.

    Now that we’ve identified some of your expenses associated with an ROI cal
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    culation, lets look at a specific campaign example and how we can determine our return on investment in a simple manner.

    Example1: MarketingScoop, LLC decides to send
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    a post card mailing to a list of small businesses promoting their directory service listing. Here is a list of expenses associated with the mailing:

    Direct Expenses
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    Post card design $100 1,000 post cards $200 Postage $500 Total $800

    Indirect Expenses Indirect Expenses X .25* $200

    A rule of thumb you can use to cal
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    culate your indirect expenses is to multiply your direct expenses by 25%. If you want a more exact determinant of indirect expense, you will have to record the amount
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    of time attributed to this particular marketing project as a percentage of your annual ‘available working hours’. Then, multiply this percentage against your total bus
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    iness expense.

    Based on our calculation above, total campaign cost equals $1,000. For this example, let’s assume that the campaign brings in $2,500 in revenue. Simpl
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    y divide revenue by expense ($2,500/$1,000) to determine ROI. In this example, our ROI was 2.5.

    Note: This is a Gross calculation which means that we have not subtrac
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    ted any product related expenses. This gets into Net Income, EBITDA, and other stuff for the accounting team to figure out.

    The key is to use this information as a be
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    nchmark for future campaigns. Instead of assuming that a marketing campaign is productive, you now have a basic measurement to evaluate it and compare future campaigns


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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