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Outclass

Outclass integrates POPFile's classification engine into Outlook.

Pros:

• You get an easy to use toolbar that lets you re-classify messages.

• You can set up "bucke

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ts" (or categories) easily and have Outclass file or delete matching messages automatically.

• Outclass works with IMAP or Exchange accounts just like incoming POP mail.

Cons:

• Som

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

users report instability and crashing under some circumstances.

• Outclass doesn't work neatly with Outlook's vertical pane layout.

SpamAid

Using Bayesian statistics from a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

database of existing spam, no initial training period is necessary.

Unfortunately you will have to rely on someone else's definition of spam in the beginning so you may see some false

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

positives right out of the box.

In addition to Bayesian filtering, SpamAid uses "blacklists" and "whitelists" to streamline spam filtering. It also uses a system of "phrase filters" t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hat you can customize.

Pros

• Uses Bayesian filtering with a high accuracy

• You can "spam-test" your own outgoing mail for its potential of being caught in someone else's spam filt

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

r

• Easy to use

Cons

• You cannot tell SpamAid to scan certain folders automatically.

• False positives can be expected when you start using it.

SpamBayes Outlook Addin

Th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e SpamBayes Outlook Addin leverages the proven track record of Bayesian spam filtering technology. Pros:

• SpamBayes can show you a detailed analysis of a message's overall spam pro

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ability.

Cons:

• Not easy to sub-categorize "good email" into separate folders

SpamCatcher Outlook

On the plus side, SpamCatcher combines a content-scoring filters with a us

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

er network that is providing feedback on their spam. It can be used as a POP proxy so you can use it with most email clients, not just Outlook.

On the negative side, you can't easily

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ustomize the filters are not customizable. This might be the reason why it returns a significant number of false positives (and negatives). Not only that: you can't submit corrections

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

o the user network with SpamCatcher.

Pros

• Easy to use

• Spam classified by the user community network as well as Bayesian analysis

• Includes automatic filter updates

Cons

• No

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t the most precise filters

• Cannot correct false positives

• Only works with POP accounts, not IMAP

Trend Micro Anti-Spam Pilot

Anti-Spam Pilot uses heuristic filters to sp

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t and isolate spam. This is a somewhat older technology where you filter the email by looking for patterns that might match a collection of known spam. For example, the anti spam softw

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

are might find certain words, phrases, punctuation, that give it a clue that this is spam in your email box. It then provides a score for the email. If the score is too high, the anti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

pam software will isolate the spam into a separate folder or do anything else you specify.

This approach is different than a Bayesian filter that actually learns as you go. The upside

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

of this is that you don't have to spend a lot of time "training" the filter. The downside is that it doesn't detect as much spam as some other packages using Bayesian technology.

You

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

do have the option of reporting missed spam (false negatives) and the rare spam emails that escape through the filter (false positives). You can also keep a list of spammers (a blackli

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

st) and a list of legitimate emailers (a whitelist) as a way to increase Anti-Spam Pilot's overall effectiveness.

Pros

• Simple and uncomplicated to use

• Detects a good deal of spa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

• Low number of false positives

• It's easy to reclassify email mistaken as spam (and vice versa)

Cons

• Does not filter IMAP accounts, only POP accounts

• Only works with Outloo

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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