Subjects - Internet and Businesses Online

POPFile

POPFile is an email classification tool that can be used to identify and isolate spam automatically.

Using Bayesian filtering, POPFile will "learn" what you teach it about sorting and stori

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ng desirable versus spam.

POPFile can be used as an SMTP proxy before you mail server to filter all your mail. This means you can use it with almost any email client. If you use an NNTP news reader, POPFil

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e can classify news items as well.

POPFile uses a web interface for configuration and correction of decisions about spam.

Pros

* Works via web interface

* Can be used as a POP proxy as NNTP

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

* Uses Bayesian filtering

Cons

* Can be a memory and CPU hog

* Not optimized for enterprise use

SpamExperts

First the good news: SpamExperts requires virtually no configuration out of th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e box.

Now the bad news: the occasional re-configuration sometimes requires a reboot.

Beyond that, SpamExperts is pretty easy to use. It uses a combination of checksum analysis and a Bayesian filter. Not

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

sure why it runs so slowly sometimes. I do know that getting your mail is going to be a two-step process: first SpamExperts has to go get and then examine your mail. It can be configured to do this in the b

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ckground. Then, you have to actually retrieve the good mail that is left.

SpamExperts will also quarantine any email it is unsure about. That way you can go in and have a look, training the Bayesian filter

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

to recognize it the next time.

Pros

* Works without any configuration

* Supports POP and IMAP accounts

Cons

* Slow to process and filter incoming mail

* Re-classifying mail isn't the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

easiest thing to do

* Cannot sort by spam score

* Changing some settings requires a reboot

Spamihilator

Spamihilator works as a proxy for POP and IMAP mail systems. This means that it

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

will work with just about any email software and isolate spam before you download it.

It uses two techniques for catching spam: A Bayesian filter and something called Distributed Checksum Clearinghouse (DC

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

C):

The basic logic in DCC is that most spam mails have several copies floating around. Any server using DCC that finds a spam email creates a checksum (adding up the basic components of the message and th

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

en creating a shorthand value). The server then posts this value to a central database. The next server receiving this email would get the DCC results and can more easily identify the email as spam.

The on

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

thing Spamihilator doesn't do is mark spam for further filtering via your email client. More than two categories of mail for automatic classification would be nice, too.

Pros

* Spamihilator can be us

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ed with any email client because it works as POP or IMAP proxy.

* Combines multiple techniques for filtering spam which makes it very effective.

Cons

* No remote web-based administration

* W

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ill not classify and/or categorize your good email

SpamPal

SpamPal uses an "a la carte" approach for eliminating spam. This means that you can mix and match various different techniques:

* Bla

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

klists

With SpamPal installed you can choose from a variety of published lists of known spammer domains and servers. If you receive mail from one of these sources, it will be identified as spam and iso

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

lated.

* Whitelists (manual and automatic)

This is a list of contacts that you decide are acceptable to receive email from and should not be sent to the trash folder. SpamPal will help you build such

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a list automatically (faster) or manually (more accurate).

* Bayesian filtering

* Content scoring

SpamPal works with any email program because it acts as a proxy.

Pros

* Uses Bayesian filte

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ing as well as many blacklists

* Works as a POP and IMAP proxy so you can use it with almost any email client

* Includes SpamAssassin (a server-side anti spam program that uses content-matching ru

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

les, as well as DNS-based, checksum-based and statistical filtering)

Cons

* SpamPal isn't fully immune to blacklist problems

* DNS blacklists are slow-performing and suck up a lot of bandwidt

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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